Hyperpyrexia Symptoms, Causes, Treatment, Management and Guidelines

Hyperpyrexia is an emergency condition where the body temperature rise above normal. Another name fore hyperpyrexia is hyperthermia. This happens when the body temperature of an infected person rise abnormally to a temperature range of about 106.7℉ and which is not due to any physical or mechanical activities. At most time, the increase in temperature happens when the part of the brain that controls the body temperature is unable to function to it best, as a result of infection, cerebral injury, trauma or due to side effect of some drugs. This increase in temperature triggers raise in muscle tightening, and therefore causes a feeling of cold in such a person experiencing hyperpyrexia.

Typically, body temperature is being regulated within a narrow range, which fluctuates predictably continusoly to adjust accordin to ambient temperature. Compensatory mechanisms for temperature regulation provide a thermal homeostasis via autonomic nervous control e.g altered muscle tone, shunt blood flow to and from peripheral vascular beds, and causing heat or heat seeking behavior.

Exogenous substances as components of the bacterial cell wall (lipopolysaccharides ), degradation products, bacterial endotoxins, drugs, immune complexes and complement factors induce activated polymorphonuclear cells to release a group of endogenous pyrogens cytokines . These cellular mediators, known as interleukins (IL) -1 and IL-6, tumor necrosis factor (TNF), and interferon G induce the production of prostaglandin E2 (PGE2) by endothelial cells. In the vascular region of the prepoptic nucleus of the anterior hypothalamus, PGE2 diffuses the short distance between the neurons of the temperature control center.

Hyperpyrexia Symptoms, Causes, Treatment, Management and Guidelines

Hyperpyrexia Symptoms

Symptoms of Hyperpyrexia include an uncontrollable increase in the body’s temperature due to inability of the body to regulate the body temperature to its normal state. Other symptoms include cold, loss of appetite, pains in the whole body or some body joints, headache and some unusual circumstances like vomiting (this usually happens in children of tender age.

Hyperpyrexia Causes

Hyperpyrexia is mainly caused by the inflammation in part of the brain called hypothalamus, which is responsible for the regulation of the body temperature. This inflammation may be associated with infection, cerebral injury, mechanical injury, trauma or accidental damage. Hyperpyrexia may also be idiopathic in nature mean it belong to unknown origin. However, it is commonly observed that some drugs like anesthetics, deploarizing agents and

Hyperpyrexia Treatments

Hyperpyrexia is an emergency medical condition. Treatment goes for the lessening of the body temperature to 39℃. Patient should be covered with wet sheets or towels and splashed with icy water while air is blown or fanned over him to advance evaporative cooling. As an option, the patient might be drenched in chilly water. The appendages are delicately kneaded to advance dissemination. At the point when the body temperature fall to 38 degrees, the patient should be shifted to a cool room and looked for further ascent of temperature.
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