Monocytosis ICD-10, Symptoms, Causes, Treatment


Monocytosis is defined as an increase in peripheral blood monocytes greater than 0.8 X 109 / L and is predominantly associated with inflammatory and immune disorders. It is difficult to connect elevated levels of monocytosis with some specific diseases, unlike neutrophils. One of the classical monocytosis associations is tuberculosis infection.

However, other infections such as subacute bacterial endocarditis, salmonellosis, listeriosis, syphilis, leprosy and brucellosis may also be associated with monocytosis. The monocytosis often occurs during the recovery phase of acute infection or after removal of the bone marrow. Monocytosis may also be associated with haematological malignancies such as myelodysplastic syndrome and certain types of acute and chronic leukemias. Interestingly, 25% of patients with Hodgkin's disease have been reported to have monocytosis.

Monocytosis may also accompany many non-hematopoietic malignancies and some vascular diseases of collagen. Thus, the detection of a monocytosis is relatively non-specific and can be associated with various haematological disorders that might be benign or malignant in natures. The mononuclear phagocytic system is also the major cell system affected in several storage disorders. These storage disorders are usually inherited disorders or enzyme deficiencies that are necessary for the storage and processing of lipids. Macrophages become the most obvious morphological anomalies in these diseases as they are filled with lipid materials that can not  be further digested.

Monocytosis ICD-10, Symptoms, Causes, Treatment

Monocytosis Symptoms

Monocytosis  is associated with inflammatory response in case of any infection, pathological disorder or autoimmune disease. Symptoms are not so obvious to distinguish it clearly from other disorders. However, some commonly reported symptoms are swelling around body especially in extremities, joints pain due to inflammatory response, fever like condition. These symptoms may vary from patient to patient depending upon the underlying cause.

Monocytosis Causes

Monocytosis is an unusual finding in children. Infection with intracellular micro-organisms or parasites is the most common cause of monocytosis. Infections include malaria, trypanosomiasis, Rickettsia disease and Listeria monacytogertes. Persistent monocytosis with unusual forms may precede various lymphoproliferative disorders and histopathological disorders such as hodgkin's disease and juvenile myelomonocytic leukemia. Some other possible causes include ulcerative colitis, regional neuritis, lipid storage disorders, neutrophil suppression, collagen vascular disease etc.

Monocytosis Treatment

Monocytosis itself does not require any treatment because it is always a manifestation of disease. So, it is important to rule underlying cause of monocytosis before treatment. If monocytosis is associated is with infection like brucellosis or tuberculosis then antibacterial therapy is much effective to bring this condition at normal level. However, if it is associated with auto immune disorder then steroidal therapy and immunosuppressant might be required.

Monocytosis ICD-10

Following code is used for monocytosis in ICD-10

D72.821--Monocytosis (symptomatic)--billable

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