Roth’s Spots Pictures, Definition, Symptoms, Causes, Treatment

A disease in which there is a hemorrhage on the retina with white or pale centers is termed as Roth’s spots. The disease was discovered and explained by a Swiss pathologist “Mortiz Roth” and hence it is named after his name. It is originally associated with a bacterial infection of heart, in which its wall “endocardium” gets swelled. Roth’s spots may also be formed in leukemia, diabetes, collagen-vascular diseases, and other conditions that predispose to hemorrhage in the retina. These spots are believed to be composed of coagulated fibrinogens which may include platelets or neoplastic cells.

Roth’s Spots Pictures


Roth’s Spots Pictures, Definition, Symptoms, Causes, Treatment

Roth’s Spots Pictures, Definition, Symptoms, Causes, Treatment



Roth’s Spots Symptoms



  • Extreme tiredness, typically resulting from mental or physical exertion or illness.
  • Repeated episodes of extreme perspiration that may soak your nightclothes or bedding this condition is called as night sweats.
  • Having temperature more than the normal body temperature this condition is termed as pyrexia or simply fever.
  • Loss of weight that causes weakness.
  • Roth’s spot due to hypertension include following
  • Pain in forehead.
  • Difficulties in breathing
  • Problems in vision.
  • Redness of eyes is also an important symptom of Roth’s spots disease.


Roth’s Spots Causes

     
The disease can be caused by following major reasons:

  • Swelling of blood vessels mediated due to immune complex resulting from bacterial infection of heart in which endocardium gets swelled.
  • Abnormal mass of blood cells those are dangerous to health.
  • Abnormal increase in growth of blood cells, the leukocytes.
  • Abnormally high sugar level in blood.
  • Sub acute bacterial endocarditis.
  • Retinal loss of vision due to human immunodeficiency virus.
  • Loss of red blood cells.
  • Deficiency of vitamin B12.
  • Restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism, to keep tissue alive.
  • Damage to the retina and retinal circulation due to high blood pressure.


Roth’s Spots Treatment

Treatment of roth's spots depends upon underlying cause e.g if endocarditis is main reason of roth's spots then treatment of infection is primary goal to removal all associated complications. Similarly, viral infection, diabetes, leukemia etc may also act as triggering factor in pathogenesis of roth's spots. It is always recommended to consult you health care provider for proper diagnosis of disease and its root cause before initiating any kind of therapeutic treatment.
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Janeway lesion Pictures, Definition, Symptoms, Causes, Treatment

The janeway  lesion is described as collection of pus that has built up within the tissues of the body with marked localized death of living tissue and inflammatory filtrate not involving the epidermis. These macules are only few millimeters in diameter. Janeway lesions are distal, flat, ecchymotic (the escape of blood into the tissues from ruptured blood vessels) and painless. Janeway lesions are named after Edward Janeway (1841–1911). He was a prominent American physician and pathologist who initially described the lesions and after brief research it is named Janeway Lesions.


Janeway lesion Pictures






Janeway lesion Symptoms



  • There are small areas of bleeding under the nails which is also called splinter hemorrhages.
  • There are red colored and painless skin spots on the flat,expanded concave part of the palms of hands between the bases of the fingers and the wrist and soles.
  • There are red colored, painful nodes when touched in the pads of the fingers and toes and these are similar to osler’s nodes.
  • There is very high shortness of breathing during light or hard activity or during exercise.
  • Swelling  and inflammation of feet, legs and the dorsal side of abdomen.
  • Irregular flat,injured and diseased spot on the skin of  hands and feet
  • These are painless skin spot but painful in osler’s nodes. 
  • The color of skin lesions may change from reddish to purplish.

Janeway lesions and Osler's nodes


According to research which is related to pathology janeway lesion is also just similar to osler’s nodes but osler’s nodes is painful when touched with finger tip or simply exerting pressure on it.


Janeway lesions Causes


  • They are caused by infected and contaminated particles circulating in the blood and deposition of  bacteria, forming a painful area of inflamed tissue that is filled with pus.
  • Janeway's lesions are caused by bacteria that have spread from an infection of the lining of the heart 
  • Janeway lessions and Osler’s nodes are may occur due to cutaneous immune-complex mediated by vasculitis, only present in around 25% of patients with inflammation of the linning of heart and its valves.
  • Janeway lesions occurs in endocarditis caused by staphylococcus aureus.
  • Janeway lesions are caused by septic emboli. 
  • Osler's nodes result from the depositing of immune complexes. 
  • The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions.
  • Serious and deadly infections if not treated became aggressive and can even result in death.

Janeway lesions Treatment

Treatment mainly depends upon the causative agent. If it happen due to infection then broad spectrum anti-biotics like aminoglycosides, fluoroquinolones, macrolides etc should be used to eradicate infection completely. It is assumed that neem oil and eucalyptus oil are very effective in the treatment of janeway lesions but it is not proved by any health authority.
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