Nulliparity Meaning, Definition, cancer risk | Nulliparity vs Primiparity

   

nulliparus or nullipara women is one, who never had a child, and this state of non productiveness is called nulliparity. Nulliparity is a recognized risk factor for cervical cancer. Most studies show a double or triple risk for women than those have given birth. The assumption that infertility is a risk factor for cervical cancer is supported by studies that show a higher risk for unmarried women than for married women. Several studies have found that infertile women have an increased risk cancer of reporductive organs due to nulliparity.

Mechanisms that can mediate the risks associated with infertility include anovulatory menstrual cycles (prolonged estrogen exposure without sufficient progesterone), elevated levels of androstenedione (ie, excess androstenedione is available for estrogen conversion) and the lack of monthly sloughing of the lining of the endometrium (i.e the residual tissue can become hyper).

In addition, nulliparity associated with lower levels of globulin bound serum sex hormone (SHBG) causing an increase in bioavailability of estrogen. In most studies, the risk of uterine cancer decreases with increasing parity, especially among women pre-tmenopausal . Several recent studies have shown that past births at the end of reproductive life may reduce the risk of uterine cancer. Although this reflects the unique hormonal profiles of women who can conceive at a later age.

The hypothesis is consistent with the observations that the risk of uterine cancer increases with time as the latest pregnancy . Additional support for this hypothesis comes from several studies that show a reduction in the risk of users of intrauterine devices. However, it is also possible that these devices may affect the risk of causing structural or biochemical changes that alter the sensitivity of the endometrium to circulating hormones.

Nulliparity Meaning, Definition, cancer risk | Nulliparity vs Primiparity

Nulliparity Cancer Risk


In most studies, the risk of uterine cancer decreases with increasing parity, especially in women having pre-menopausal phase. Because pregnancy and breastfeeding reduces the number of women's menstrual cycles in her lifetime, that's why birth is associated with lower cumulative exposure to endogenous hormones.

In addition, pregnancy and breastfeeding make breast cells differentiation and mature them for production of milk. There is a hypothesis, from some researchers, that this differentiation makes breast cells more resistant to transformation in cancer cells than cells that have not undergone such differentiation. Some statistics show that nulliparity (never having had children) is associated with a three times higher risk of breast cancer.

Nulliparity vs Primiparity


A nulliparus or nullipara women is one, who never had a child, and this state of non productiveness is called not nulliparity while Parity is the condition of being able to have children, and when the woman becomes pregnant for the first time enters the state of primiparity, and is called primiparity woman, and primipara or primigravida. Similarly mulitple birth is termed as multiparity.


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